Path_To_Unpin = r"C:\ProgramData\Shared Space"

import os
from subprocess import PIPE, Popen
import ctypes

class disable_file_system_redirection:
    _disable = ctypes.windll.kernel32.Wow64DisableWow64FsRedirection
    _revert = ctypes.windll.kernel32.Wow64RevertWow64FsRedirection
    def __enter__(self):
        self.old_value = ctypes.c_long()
        self.success = self._disable(ctypes.byref(self.old_value))
    def __exit__(self, type, value, traceback):
        if self.success:
            self._revert(self.old_value)

def ecmd(command):   
    from subprocess import Popen, PIPE
    import ctypes
    
    with disable_file_system_redirection():
        obj = Popen(command, shell = True, stdout = PIPE, stderr = PIPE)
    out, err = obj.communicate()
    ret=obj.returncode
    return ret,out,err

cmd = '((New-Object -ComObject shell.application).Namespace("shell:::{679F85CB-0220-4080-B29B-5540CC05AAB6}").Items() | Where-Object { $_.Path -EQ \'%s\' }).InvokeVerb("unpinfromhome")'%(Path_To_Unpin)

ret,out,err = ecmd(['powershell', cmd])
if ret==0:
    if out:
        print(out)
    print('successfully Unpinned this path "%s" from Quick Access'%(Path_To_Unpin))
else:
    if err:
        print(err)
    else:
        print("something went wrong. Return code: %s"%(ret))